Relative Effectiveness of the Cell-derived Inactivated Quadrivalent Influenza Vaccine Versus Egg-derived Inactivated Quadrivalent Influenza Vaccines in Preventing Influenza-related Medical Encounters During the 2018–2019 Influenza Season in the United States
Constantina Boikos, Lauren Fischer, Dan O’Brien, Joe Vasey, Gregg C Sylvester, James A Mansi
This study estimated the relative vaccine effectiveness (rVE) of ccIIV4 versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018–2019 US season.
The Impact of COVID-19 on the Use of Preventive Health Care
Katie Martin, Daniel Kurowski, Phillip Given, Kevin Kennedy, Elianna Clayton
HCCI’s work shows submitted claims for most preventive services we examined, such as mammography and childhood immunizations exhibited significant declines in 2020 compared to 2019, particularly mid-March through mid-April. Even by June 2020 utilization of many preventive services appeared to be running below 2019 levels
Analysis of Electronic Medical Record Data Shows Significantly Higher Rates of COVID-19 Infection among Hispanic and Black Patients
Daniel Kurowski, Katie Martin, Anna Milewski, Angela Pupino, Niall Brennan
For the sample population, the disparity in infections among Black and Hispanic communities is significantly higher than most current assumptions. Additionally, patients presenting in an office or clinic setting who test positive are more likely to be younger and less likely to be older than 65.
Further Evidence That COVID-19 Disproportionately Impacts African American, Hispanic, and Low-Income Populations
Dustin D. French, Andrew Chin, and Pooja Kathail
Utilizing consumer data, mortality data, and medical claims data from the COVID-19 Research Database, French, Chin, and Kathail helped quantify the disproportionate impact that COVID-19 has across different racial and socioeconomic groups. For instance, the bottom quartile of income distribution (under $49,000 in annual income) have 30 percent of COVID cases and 46 percent of COVID deaths. Meanwhile, the top quartile (over $144,000 in annual income) had only 11 percent of COVID deaths.
Socioeconomic Network Heterogeneity and Pandemic Policy Response
Mohammad Akbarpour, Cody Cook, Aude Marzuoli, Simon Mongey, Abhishek Nagaraj, Matteo Saccarolak, Pietro Tebaldi, Shoshana Vasserman, and Hanbin Yang
Researchers from Harvard, Stanford, the University of Chicago, and Berkeley created a methodology for deciding which locations in a city to re-open and which to keep closed. The authors utilized a wide variety of data sources to build their models, including electronic medical records from the COVID-19 Research Database. After its completion, the model was then tested across three different cities: Chicago, Sacramento, and New York.
Computable Phenotype Implementation for a National, Multicenter Pragmatic Clinical Trial: Lessons Learned From ADAPTABLE
Faraz S. Ahmad, Iben M. Ricket, Bradley G. Hammill, Lisa Eskenazi, Holly R. Robertson, Lesley H. Curtis, Cecilia D. Dobi, Saket Girotra, Kevin Haynes, Jorge R. Kizer, Sunil Kripalani, Mathew T. Roe, Christianne L. Roumie, Russ Waitman, W. Schuyler Jones, and Mark G. Weiner
This study outlines the recruitment process for the ADAPTABLE study (Aspirin Dosing: a Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness), a pragmatic, randomized, open-label clinical trial that tested the optimal dose of aspirin for secondary prevention of atherosclerotic cardiovascular disease events. Investigators identified 650,000 potential eligible patients and recruited them at community sites, linking together data from the 40 sites in the Patient-Centered Outcomes Research Network to understand eligibility. The study was ultimately able to successfully enroll 15,076 patients in a significantly lower-cost way than most trials.
Daily Deaths During Coronavirus Pandemic by State
John Hargraves and Daniel Kurowski
Using mortality data, the Health Care Cost Institute found that daily deaths in the United States were over 10 percent higher in 2020 than they had been in previous years. The data showed dramatic variations by geography. Since the end of March, New York daily death figures were double those from previous years. While New York deaths appeared to be declining by April, other states were on the rise.
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